Advancing Integrated Models (AIM) of Care to Improve Maternal Health Outcomes among Women Who Experience Persistent Disparities (R01 Clinical Trial Required) | RFA NR 22 002

Opportunity Information: Apply for RFA NR 22 002

The Advancing Integrated Models (AIM) of Care to Improve Maternal Health Outcomes among Women Who Experience Persistent Disparities funding opportunity (RFA-NR-22-002) is a National Institutes of Health (NIH) discretionary grant initiative designed to confront persistent and unequal maternal health outcomes in the United States. It frames severe maternal morbidity and maternal mortality disparities as an urgent public health crisis and calls for intervention-focused research that goes beyond describing the problem to testing real-world solutions. The core aim is to generate new evidence on how integrated models of care can be developed, implemented, and evaluated in ways that directly address structural inequities and measurably reduce adverse maternal outcomes in populations that have been disproportionately impacted.

This opportunity supports R01-level research projects and explicitly requires a clinical trial, meaning applicants are expected to study an intervention in a systematic way that can produce actionable findings about what works, for whom, and under what conditions. The emphasis on "integrated models of care" signals a focus on coordinated, multi-component approaches rather than isolated clinical services. In practice, this can include interventions that connect medical care with behavioral health, social services, community-based supports, and systems-level changes across the prenatal, perinatal, and postpartum continuum. The initiative is particularly interested in models that can prevent adverse outcomes and reduce inequities by addressing upstream drivers such as structural barriers to access, fragmented care delivery, and institutional or policy-level factors that shape risk and outcomes.

Eligibility is broad and intentionally inclusive to encourage partnerships across healthcare, public health, education, and community settings. Eligible applicants include state, county, city, township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; tribal organizations that are not federally recognized; public housing authorities/Indian housing authorities; nonprofits with and without 501(c)(3) status; for-profit organizations (other than small businesses); and small businesses. The announcement also highlights additional eligible applicant types such as Historically Black Colleges and Universities (HBCUs), Hispanic-serving Institutions, Tribally Controlled Colleges and Universities (TCCUs), Alaska Native and Native Hawaiian Serving Institutions, and Asian American Native American Pacific Islander Serving Institutions (AANAPISISs), as well as faith-based or community-based organizations, eligible federal agencies, regional organizations, and U.S. territories or possessions. This mix underscores the expectation that effective interventions may require collaboration across institutions and sectors, especially those closely connected to communities experiencing the greatest burden.

There are important limits on foreign involvement. Non-domestic (non-U.S.) entities and non-domestic components of U.S. organizations are not eligible to apply as applicants. However, foreign components are allowed as defined in the NIH Grants Policy Statement, which generally means a U.S.-based applicant can include certain foreign collaborations or activities when well-justified and compliant with NIH policy, but the applicant organization itself must be U.S.-based and the project cannot be led by a non-U.S. institution.

Administratively, the opportunity is categorized under education, health, income security, and social services, and is associated with CFDA numbers 93.307, 93.313, 93.361, and 93.865. The original closing date listed for the competition was April 7, 2022, and the posting was created on January 26, 2022. While the award ceiling and expected number of awards are not specified in the provided data, the overall structure signals an NIH-style research grant focused on rigorous intervention testing, implementation in real-world settings, and evidence generation that can inform scalable strategies to reduce severe maternal morbidity and mortality disparities.

• The National Institutes of Health in the education, health, income security and social services sector is offering a public funding opportunity titled "Advancing Integrated Models (AIM) of Care to Improve Maternal Health Outcomes among Women Who Experience Persistent Disparities (R01 Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.307, 93.313, 93.361, 93.865.
• This funding opportunity was created on 2022-01-26.
• Applicants must submit their applications by 2022-04-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA NR 22 002

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