Core State Injury Prevention Program (Core SIPP) | CDC RFA CE21 2101

Opportunity Information: Apply for CDC RFA CE21 2101

The Core State Injury Prevention Program (Core SIPP) is a CDC cooperative agreement designed to strengthen the ability of health departments and their partners to prevent injuries and injury-related deaths using data-driven public health practice. The funding focuses on building and sustaining the core infrastructure needed to detect, understand, and respond to both ongoing and emerging injury threats. At its center, the program emphasizes using the best available evidence to reduce risk factors, increase protective factors, and translate surveillance findings into practical prevention actions that can be implemented and evaluated in real-world settings.

A key feature of the opportunity is its strong emphasis on data and surveillance as the foundation for decision-making. Recipients are expected to improve how they collect, analyze, and use injury data to identify trends, characterize populations at risk, and spot new threats early. This includes strengthening injury surveillance systems, improving data quality and timeliness, and ensuring findings are shared in ways that inform policy, programs, and community-level interventions. The program also highlights assessment and evaluation, meaning recipients are expected not only to implement activities but to measure progress, learn what works locally, and use results to refine strategies over time.

Partnership development is another central requirement. Core SIPP supports strategic collaborations across sectors that influence injury prevention, such as public health, healthcare systems, transportation, education, social services, emergency medical services, and community organizations. The intention is to help jurisdictions move beyond isolated efforts and toward coordinated prevention approaches where data, expertise, and implementation capacity are shared. These partnerships are meant to strengthen the reach and effectiveness of prevention actions and to help align efforts around common priorities.

All funded recipients are expected to focus their strategic efforts on three priority areas: traumatic brain injury (TBI), transportation-related injury, and Adverse Childhood Experiences (ACEs). This means grantees should use local and state data to guide prevention planning, coordinate partners, and support actions that address these areas in meaningful ways. At the same time, the program allows flexibility so recipients can respond to what their data shows is most urgent in their communities. Specifically, recipients are encouraged to use up to 25 percent of their award to address additional locally identified injury priorities, such as drowning, older adult falls, or suicide, as long as those priorities are supported by data and fit within an injury-prevention public health approach.

The opportunity also includes an enhanced funding component for recipients that are prepared to go beyond infrastructure and coordination into implementation and evaluation of prevention strategies, while incorporating novel surveillance activities. The point of this enhanced component is to generate practice-based evidence: lessons and results drawn from real implementation conditions that can help strengthen the overall evidence base for injury prevention. In other words, the program is set up not only to apply existing evidence, but also to contribute new knowledge about what works, for whom, and under what circumstances.

Administratively, the grant is offered by the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, specifically through the National Center for Injury Prevention and Control (NCIPC). It is categorized as a discretionary award and uses a cooperative agreement funding instrument, which typically means CDC expects substantial involvement through technical assistance, collaboration, and ongoing engagement rather than a hands-off grant model. The Assistance Listing (CFDA) number is 93.136. The opportunity number is CDC RFA CE21 2101, originally posted on February 18, 2021, with an original application due date of April 19, 2021 (with electronic submissions due by 11:59 p.m. Eastern Time).

Eligibility is broad and includes state, county, city, and township governments; special district governments; independent school districts; public and private institutions of higher education; federally recognized tribal governments and other tribal organizations; public housing authorities/Indian housing authorities; nonprofit organizations with or without 501(c)(3) status (excluding higher education institutions in those nonprofit categories); and for-profit organizations, including small businesses. The award ceiling listed is $400,000, and CDC anticipated making about 29 awards under this NOFO. Overall, Core SIPP is structured to help jurisdictions build the foundational systems, partnerships, and analytic capacity needed for modern injury prevention, while also supporting targeted action and evaluation that can lead to measurable reductions in injury risk and harm.

• The Department of Health and Human Services, Centers for Disease Control - NCIPC in the health sector is offering a public funding opportunity titled "Core State Injury Prevention Program (Core SIPP)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.136.
• This funding opportunity was created on Feb 18, 2021.
• Applicants must submit their applications by Apr 19, 2021 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $400,000.00 in funding.
• The number of recipients for this funding is limited to 29 candidate(s).
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.

Apply for CDC RFA CE21 2101

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