Opportunity Information: Apply for RFA CA 17 019
The National Institutes of Health, through the National Cancer Institute (NCI), released a discretionary grant funding opportunity titled "Revision Applications to NCI-supported R01 Awards to Include Research on the NCI's Provocative Questions (R01)" (Funding Opportunity Number RFA-CA-17-019). The main purpose of this announcement is to encourage investigators who already hold an active NCI-funded R01 award to submit a revision application that adds new work to their existing project. Rather than funding an entirely new, stand-alone study, this mechanism is meant to expand the scope of an ongoing R01 by adding additional specific aims that align with one of NCI's Provocative Questions (PQs).
A key feature of this opportunity is its tight thematic focus: proposed revisions are expected to directly address one of 12 specific Provocative Questions identified by NCI and published for new applications under related FOAs (RFA-CA-17-017 for R01s and RFA-CA-17-018 for R21s). In practical terms, applicants are being asked to connect their proposed expansion to one clearly relevant PQ area and explain how the added aims will meaningfully advance knowledge or practice in cancer research. The announcement is also designed to promote work that strengthens the broader PQ initiative, including studies that validate outcomes from prior PQ-related research, or efforts that help adopt, translate, disseminate, and otherwise move PQ-driven findings toward real-world impact in cancer research and clinical care.
Because this is a revision (often understood as a "competing revision") to an existing R01, the proposed research must be additive and justified as an extension of the parent grant. The new studies should be framed as additional specific aims that expand what the already-funded project can accomplish, rather than simply continuing the same work. This structure encourages investigators to leverage the infrastructure, data, cohorts, methods, or collaborations already established under the parent R01, while using the revision to pursue a targeted PQ-related question that was not part of the original scope.
The opportunity falls under the NIH grant funding instrument type and is categorized under education and health funding activities. It lists multiple CFDA numbers associated with NCI programs (93.393, 93.394, 93.395, 93.396, and 93.399), reflecting that awards may align with different NCI funding streams within the broader cancer research mission. The posted award ceiling for this FOA is $150,000, signaling that the revision budget is intended to be relatively limited and focused, consistent with adding a defined set of new aims rather than financing a large expansion.
Eligibility is broad in terms of institutional types, which is typical for NIH opportunities, but the applicant must have an active NCI R01 to be eligible for the revision mechanism. Eligible applicants include a wide range of U.S. organizations such as state, county, and local governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; nonprofit organizations with or without 501(c)(3) status (excluding institutions of higher education in those categories); for-profit organizations (including entities other than small businesses); and small businesses. It also includes Native American tribal governments (federally recognized) and tribal organizations other than federally recognized governments, as well as public housing authorities and Indian housing authorities. Beyond these standard categories, the FOA explicitly highlights additional eligible applicant types, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal agencies, regional organizations, U.S. territories or possessions, and even non-U.S. (foreign) entities.
Important administrative details in the source information include the original closing date of January 23, 2018, and a creation date of March 13, 2017. In short, this FOA was built to accelerate progress on NCI's Provocative Questions by giving currently funded NCI R01 investigators a structured, time-limited way to add PQ-centered aims to an active grant, with an emphasis on direct PQ relevance and potential downstream impact on cancer research and patient care.Apply for RFA CA 17 019
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "Revision Applications to NCI-supported R01 Awards to Include Research on the NCI's Provocative Questions (R01)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.393, 93.394, 93.395, 93.396, 93.399.
- This funding opportunity was created on 2017-03-13.
- Applicants must submit their applications by 2018-01-23. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $150,000.00 in funding.
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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Applicants who have applied for this opportunity (RFA CA 17 019) also looked into and applied for these:
| Funding Opportunity |
|---|
| Supplements for Validating the Use of Automated Sources of Residential Histories in Cancer Epidemiology Cohorts (Admin Supp) Apply for PA 17 222 Funding Number: PA 17 222 Agency: National Institutes of Health Category: Education, Health Funding Amount: $125,000 |
| Research Supplements to Promote Sharing Data in Cancer Epidemiology Studies (Admin Supp) Apply for PA 17 224 Funding Number: PA 17 224 Agency: National Institutes of Health Category: Education, Health Funding Amount: $100,000 |
| Supplement Opportunity to Support Population-Based Research Studies of Rare Cancers (Admin Supp) Apply for PA 17 223 Funding Number: PA 17 223 Agency: National Institutes of Health Category: Education, Health Funding Amount: $150,000 |
| Advancing the Science of Geriatric Palliative Care (R01) Apply for PA 17 225 Funding Number: PA 17 225 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Advancing the Science of Geriatric Palliative Care (R21) Apply for PA 17 226 Funding Number: PA 17 226 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Core Infrastructure and Methodological Research for Cancer Epidemiology Cohorts (U01) Apply for PAR 17 233 Funding Number: PAR 17 233 Agency: National Institutes of Health Category: Education, Health Funding Amount: $1,250,000 |
| Mechanisms and Consequences of Sleep Disparities in the U.S. (R21) Apply for PAR 17 235 Funding Number: PAR 17 235 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Innovative Research in Cancer Nanotechnology (IRCN) (R01) Apply for PAR 17 240 Funding Number: PAR 17 240 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
| Mechanisms and Consequences of Sleep Disparities in the U.S. (R01) Apply for PAR 17 234 Funding Number: PAR 17 234 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Fostering Research Training and Education Programs for Native American Students at NCI-designated Cancer Centers (Admin Supp) Apply for PA 17 241 Funding Number: PA 17 241 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Avenir Award Program for Research on Substance Abuse and HIV/AIDS (DP2) Apply for RFA DA 18 004 Funding Number: RFA DA 18 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Secondary Analysis and Integration of Existing Data to Elucidate the Genetic Architecture of Cancer Risk and Related Outcomes (R21) Apply for PA 17 243 Funding Number: PA 17 243 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Secondary Analysis and Integration of Existing Data to Elucidate the Genetic Architecture of Cancer Risk and Related Outcomes (R01) Apply for PA 17 239 Funding Number: PA 17 239 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Activities to Promote Research Collaborations on Immune-Related Adverse Events (APRC-irAEs) Associated with Cancer Immunotherapy (Admin Supp) Apply for PA 17 248 Funding Number: PA 17 248 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Collaborative Research Projects to Enhance Applicability of Mammalian Models for Translational Research (Collaborative R01) Apply for PAR 17 244 Funding Number: PAR 17 244 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
| Extracellular Vesicles and Substance Use Disorders (R21) Apply for PAR 17 242 Funding Number: PAR 17 242 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Research Projects to Enhance Applicability of Mammalian Models for Translational Research (R01) Apply for PAR 17 245 Funding Number: PAR 17 245 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
| Extracellular Vesicles and Substance Use Disorders (R01) Apply for PAR 17 250 Funding Number: PAR 17 250 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Expanding Medication Assisted Treatment for Opioid Use Disorders in the Context of the SAMHSA Opioid STR Grants (R21/R33) Apply for RFA DA 18 005 Funding Number: RFA DA 18 005 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
| Nasal Delivery of CNS Therapeutics (R43/R44) Apply for RFA DA 18 006 Funding Number: RFA DA 18 006 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
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